| March |
| 3/313/313/313/313/31 | at KAN (WP: J.Weaver; LP: L.Hochevar) | W - 4-2 | Wrap | Box |
| April |
| 4/014/014/014/014/02 | at KAN (WP: J.Soria; LP: M.Kohn) | L - 1-2 | Wrap | Box |
| 4/024/024/024/024/02 | at KAN (WP: A.Crow; LP: K.Jepsen) | L - 4-5 | Wrap | Box |
| 4/034/034/034/034/03 | at KAN (WP: T.Collins; LP: J.Bulger) | L - 9-12 (13th) | Wrap | Box |
| 4/054/054/054/054/05 | at TAM (WP: J.Weaver; LP: J.Niemann) | W - 5-3 | Wrap | Box |
| 4/064/064/064/064/06 | at TAM (WP: D.Haren; LP: J.Hellickson) | W - 5-1 | Wrap | Box |
| 4/084/084/084/084/09 | vs. TOR (WP: O.Dotel; LP: E.Santana) | L - 2-3 | Wrap | Box |
| 4/094/094/094/094/10 | vs. TOR (WP: D.Haren; LP: J.Rauch) | W - 6-5 (14th) | Wrap | Box |
| 4/104/104/104/104/10 | vs. TOR (WP: J.Weaver; LP: J.Reyes) | W - 3-1 | Wrap | Box |
| 4/114/114/114/114/12 | vs. CLE (WP: M.Talbot; LP: T.Chatwood) | L - 0-4 | Wrap | Box |
| 4/124/124/124/124/13 | vs. CLE (WP: D.Haren; LP: R.Hernandez) | W - 2-0 | Wrap | Box |
| 4/134/134/134/134/14 | vs. CLE (WP: H.Takahashi; LP: C.Durbin) | W - 4-3 (12th) | Wrap | Box |
| 4/154/154/154/154/16 | at CWS (WP: J.Weaver; LP: P.Humber) | W - 4-3 | Wrap | Box |
| 4/164/164/164/164/16 | at CWS (WP: T.Chatwood; LP: G.Floyd) | W - 7-2 | Wrap | Box |
| 4/174/174/174/174/17 | at CWS (WP: D.Haren; LP: M.Buehrle) | W - 4-2 | Wrap | Box |
| 4/184/184/184/184/19 | at TEX (WP: C.Wilson; LP: E.Santana) | L - 1-7 | Wrap | Box |
| 4/194/194/194/194/20 | at TEX (WP: M.Palmer; LP: C.Lewis) | W - 15-4 | Wrap | Box |
| 4/204/204/204/204/21 | at TEX (WP: J.Weaver; LP: M.Harrison) | W - 4-1 | Wrap | Box |
| 4/214/214/214/214/22 | vs. BOS (WP: B.Jenks; LP: R.Thompson) | L - 2-4 (11th) | Wrap | Box |
| 4/224/224/224/224/23 | vs. BOS (WP: J.Lester; LP: D.Haren) | L - 3-4 | Wrap | Box |
| 4/234/234/234/234/24 | vs. BOS (WP: D.Matsuzaka; LP: E.Santana) | L - 0-5 | Wrap | Box |
| 4/244/244/244/244/24 | vs. BOS (WP: J.Lackey; LP: M.Palmer) | L - 0-7 | Wrap | Box |
| 4/254/254/254/254/26 | vs. OAK (WP: J.Weaver; LP: G.Gonzalez) | W - 5-0 | Wrap | Box |
| 4/264/264/264/264/27 | vs. OAK (WP: T.Chatwood; LP: B.McCarthy) | W - 8-3 | Wrap | Box |
| 4/274/274/274/274/28 | vs. OAK (WP: B.Fuentes; LP: J.Walden) | L - 1-2 (10th) | Wrap | Box |
| 4/294/294/294/294/30 | at TAM (WP: E.Santana; LP: D.Price) | W - 8-5 | Wrap | Box |
| 4/304/304/304/304/30 | at TAM (WP: J.Peralta; LP: F.Rodney) | L - 1-2 (10th) | Wrap | Box |
| May |
| 5/015/015/015/015/01 | at TAM (WP: R.Thompson; LP: J.Peralta) | W - 6-5 | Wrap | Box |
| 5/025/025/025/025/03 | at BOS (WP: C.Buchholz; LP: J.Weaver) | L - 5-9 | Wrap | Box |
| 5/035/035/035/035/04 | at BOS (WP: J.Lester; LP: D.Haren) | L - 3-7 | Wrap | Box |
| 5/045/045/045/045/05 | at BOS (WP: T.Bell; LP: D.Matsuzaka) | W - 5-3 (13th) | Wrap | Box |
| 5/055/055/055/055/05 | at BOS (WP: J.Pineiro; LP: J.Lackey) | W - 11-0 | Wrap | Box |
| 5/065/065/065/065/07 | vs. CLE (WP: F.Rodney; LP: J.Germano) | W - 2-1 (11th) | Wrap | Box |
| 5/075/075/075/075/08 | vs. CLE (WP: A.White; LP: J.Weaver) | L - 3-4 | Wrap | Box |
| 5/085/085/085/085/08 | vs. CLE (WP: F.Rodney; LP: J.Smith) | W - 6-5 | Wrap | Box |
| 5/095/095/095/095/10 | vs. CWS (WP: E.Jackson; LP: E.Santana) | L - 0-8 | Wrap | Box |
| 5/105/105/105/105/11 | vs. CWS (WP: J.Pineiro; LP: J.Danks) | W - 6-2 | Wrap | Box |
| 5/115/115/115/115/12 | vs. CWS (WP: S.Santos; LP: K.Jepsen) | L - 4-6 (10th) | Wrap | Box |
| 5/135/135/135/135/14 | at TEX (WP: A.Ogando; LP: J.Weaver) | L - 1-4 | Wrap | Box |
| 5/145/145/145/145/14 | at TEX (WP: S.Downs; LP: D.Oliver) | W - 3-2 | Wrap | Box |
| 5/155/155/155/155/15 | at TEX (WP: M.Lowe; LP: R.Thompson) | L - 4-5 | Wrap | Box |
| 5/165/165/165/165/17 | at OAK (WP: G.Balfour; LP: F.Rodney) | L - 4-5 (10th) | Wrap | Box |
| 5/175/175/175/175/18 | at OAK (WP: G.Gonzalez; LP: T.Chatwood) | L - 0-14 | Wrap | Box |
| 5/185/185/185/185/19 | at SEA (WP: J.Vargas; LP: J.Weaver) | L - 0-3 | Wrap | Box |
| 5/195/195/195/195/19 | at SEA (WP: D.Pauley; LP: S.Downs) | L - 1-2 | Wrap | Box |
| 5/205/205/205/205/21 | vs. ATL (WP: E.Santana; LP: T.Hudson) | W - 9-0 | Wrap | Box |
| 5/215/215/215/215/22 | vs. ATL (WP: S.Proctor; LP: T.Bell) | L - 4-5 (12th) | Wrap | Box |
| 5/225/225/225/225/22 | vs. ATL (WP: T.Chatwood; LP: D.Lowe) | W - 4-1 | Wrap | Box |
| 5/235/235/235/235/24 | vs. OAK (WP: S.Downs; LP: B.Fuentes) | W - 4-1 | Wrap | Box |
| 5/245/245/245/245/25 | vs. OAK (WP: G.Moscoso; LP: D.Haren) | L - 1-6 | Wrap | Box |
| 5/255/255/255/255/26 | vs. OAK (WP: E.Santana; LP: T.Cahill) | W - 4-1 | Wrap | Box |
| 5/265/265/265/265/26 | vs. OAK (WP: B.Anderson; LP: J.Pineiro) | L - 3-4 | Wrap | Box |
| 5/275/275/275/275/28 | at MIN (WP: S.Downs; LP: J.Hoey) | W - 6-5 | Wrap | Box |
| 5/285/285/285/285/29 | at MIN (WP: A.Burnett; LP: H.Takahashi) | L - 0-1 (10th) | Wrap | Box |
| 5/295/295/295/295/29 | at MIN (WP: D.Haren; LP: C.Pavano) | W - 6-5 | Wrap | Box |
| 5/305/305/305/305/30 | at KAN (WP: K.Jepsen; LP: J.Soria) | W - 10-8 | Wrap | Box |
| 5/315/315/315/316/01 | at KAN (WP: J.Francis; LP: J.Pineiro) | L - 3-7 | Wrap | Box |
| June |
| 6/016/016/016/016/01 | at KAN (WP: T.Collins; LP: S.Downs) | L - 0-2 | Wrap | Box |
| 6/036/036/036/036/04 | vs. NYY (WP: J.Weaver; LP: I.Nova) | W - 3-2 | Wrap | Box |
| 6/046/046/046/046/05 | vs. NYY (WP: C.Sabathia; LP: E.Santana) | L - 2-3 | Wrap | Box |
| 6/056/056/056/056/05 | vs. NYY (WP: B.Colon; LP: J.Pineiro) | L - 3-5 | Wrap | Box |
| 6/066/066/066/066/07 | vs. TAM (WP: D.Price; LP: T.Chatwood) | L - 1-5 | Wrap | Box |
| 6/076/076/076/076/08 | vs. TAM (WP: A.Cobb; LP: D.Haren) | L - 1-4 | Wrap | Box |
| 6/086/086/086/086/09 | vs. TAM (WP: J.Cruz; LP: F.Rodney) | L - 3-4 (10th) | Wrap | Box |
| 6/106/106/106/106/11 | vs. KAN (WP: J.Francis; LP: E.Santana) | L - 2-4 | Wrap | Box |
| 6/116/116/116/116/12 | vs. KAN (WP: S.Downs; LP: T.Collins) | W - 7-5 | Wrap | Box |
| 6/126/126/126/126/12 | vs. KAN (WP: V.Mazzaro; LP: T.Chatwood) | L - 0-9 | Wrap | Box |
| 6/136/136/136/136/14 | at SEA (WP: D.Haren; LP: J.Vargas) | W - 6-3 | Wrap | Box |
| 6/146/146/146/146/15 | at SEA (WP: J.Weaver; LP: D.Fister) | W - 4-0 | Wrap | Box |
| 6/156/156/156/156/16 | at SEA (WP: E.Bedard; LP: E.Santana) | L - 1-3 | Wrap | Box |
| 6/176/176/176/176/18 | at NYM (WP: J.Pineiro; LP: C.Capuano) | W - 4-3 | Wrap | Box |
| 6/186/186/186/186/19 | at NYM (WP: M.Pelfrey; LP: D.Haren) | L - 1-6 | Wrap | Box |
| 6/196/196/196/196/19 | at NYM (WP: T.Chatwood; LP: J.Niese) | W - 7-3 | Wrap | Box |
| 6/206/206/206/206/21 | at MIA (WP: J.Weaver; LP: S.Cishek) | W - 2-1 | Wrap | Box |
| 6/216/216/216/216/22 | at MIA (WP: J.Vazquez; LP: E.Santana) | L - 2-5 | Wrap | Box |
| 6/226/226/226/226/23 | at MIA (WP: J.Walden; LP: B.Badenhop) | W - 6-5 (10th) | Wrap | Box |
| 6/246/246/246/246/25 | at LOS (WP: D.Haren; LP: R.De La Rosa) | W - 8-3 | Wrap | Box |
| 6/256/256/256/256/25 | at LOS (WP: T.Chatwood; LP: H.Kuroda) | W - 6-1 | Wrap | Box |
| 6/266/266/266/266/26 | at LOS (WP: C.Kershaw; LP: J.Walden) | L - 2-3 | Wrap | Box |
| 6/276/276/276/276/28 | vs. WAS (WP: S.Downs; LP: S.Burnett) | W - 4-3 (10th) | Wrap | Box |
| 6/286/286/286/286/29 | vs. WAS (WP: H.Takahashi; LP: C.Balester) | W - 11-5 | Wrap | Box |
| 6/296/296/296/296/30 | vs. WAS (WP: D.Haren; LP: J.Zimmermann) | W - 1-0 | Wrap | Box |
| July |
| 7/017/017/017/017/02 | vs. LOS (WP: H.Kuroda; LP: T.Chatwood) | L - 0-5 | Wrap | Box |
| 7/027/027/027/027/03 | vs. LOS (WP: J.Weaver; LP: C.Kershaw) | W - 7-1 | Wrap | Box |
| 7/037/037/037/037/04 | vs. LOS (WP: E.Santana; LP: C.Billingsley) | W - 3-1 | Wrap | Box |
| 7/047/047/047/047/05 | vs. DET (WP: J.Pineiro; LP: C.Furbush) | W - 5-1 | Wrap | Box |
| 7/057/057/057/057/06 | vs. DET (WP: D.Haren; LP: J.Verlander) | W - 1-0 | Wrap | Box |
| 7/067/067/067/067/06 | vs. DET (WP: B.Penny; LP: H.Takahashi) | L - 4-5 | Wrap | Box |
| 7/077/077/077/077/08 | vs. SEA (WP: J.Weaver; LP: D.Fister) | W - 5-1 | Wrap | Box |
| 7/087/087/087/087/09 | vs. SEA (WP: J.Walden; LP: D.Pauley) | W - 4-3 | Wrap | Box |
| 7/097/097/097/097/10 | vs. SEA (WP: J.Pineiro; LP: M.Pineda) | W - 9-3 | Wrap | Box |
| 7/107/107/107/107/10 | vs. SEA (WP: D.Haren; LP: D.Pauley) | W - 4-2 | Wrap | Box |
| 7/157/157/157/157/16 | at OAK (WP: B.McCarthy; LP: D.Haren) | L - 3-5 | Wrap | Box |
| 7/167/167/167/167/16 | at OAK (WP: J.Weaver; LP: T.Cahill) | W - 4-2 | Wrap | Box |
| 7/167/167/167/167/17 | at OAK (WP: B.Ziegler; LP: R.Thompson) | L - 3-4 (10th) | Wrap | Box |
| 7/177/177/177/177/17 | at OAK (WP: G.Gonzalez; LP: J.Pineiro) | L - 1-9 | Wrap | Box |
| 7/197/197/197/197/20 | vs. TEX (WP: A.Ogando; LP: T.Chatwood) | L - 0-7 | Wrap | Box |
| 7/207/207/207/207/21 | vs. TEX (WP: H.Takahashi; LP: T.Hunter) | W - 9-8 | Wrap | Box |
| 7/217/217/217/217/21 | vs. TEX (WP: J.Weaver; LP: C.Wilson) | W - 1-0 | Wrap | Box |
| 7/227/227/227/227/23 | at BAL (WP: E.Santana; LP: A.Simon) | W - 6-1 | Wrap | Box |
| 7/237/237/237/237/24 | at BAL (WP: B.Bergesen; LP: J.Pineiro) | L - 2-3 | Wrap | Box |
| 7/247/247/247/247/24 | at BAL (WP: T.Chatwood; LP: J.Guthrie) | W - 9-3 | Wrap | Box |
| 7/257/257/257/257/26 | at CLE (WP: T.Sipp; LP: J.Walden) | L - 2-3 | Wrap | Box |
| 7/267/267/267/267/27 | at CLE (WP: J.Weaver; LP: J.Tomlin) | W - 2-1 | Wrap | Box |
| 7/277/277/277/277/27 | at CLE (WP: E.Santana; LP: D.Huff) | W - 3-1 | Wrap | Box |
| 7/287/287/287/287/28 | at DET (WP: B.Cassevah; LP: B.Penny) | W - 12-7 | Wrap | Box |
| 7/297/297/297/297/30 | at DET (WP: R.Porcello; LP: T.Chatwood) | L - 2-12 | Wrap | Box |
| 7/307/307/307/307/30 | at DET (WP: D.Haren; LP: J.Turner) | W - 5-1 | Wrap | Box |
| 7/317/317/317/317/31 | at DET (WP: J.Verlander; LP: J.Weaver) | L - 2-3 | Wrap | Box |
| August |
| 8/028/028/028/028/03 | vs. MIN (WP: E.Santana; LP: B.Duensing) | W - 5-1 | Wrap | Box |
| 8/038/038/038/038/04 | vs. MIN (WP: A.Swarzak; LP: J.Pineiro) | L - 4-11 | Wrap | Box |
| 8/048/048/048/048/05 | vs. MIN (WP: D.Haren; LP: F.Liriano) | W - 7-1 | Wrap | Box |
| 8/058/058/058/058/06 | vs. SEA (WP: J.Walden; LP: D.Cortes) | W - 1-0 (10th) | Wrap | Box |
| 8/068/068/068/068/07 | vs. SEA (WP: B.Beavan; LP: T.Chatwood) | L - 1-5 | Wrap | Box |
| 8/078/078/078/078/07 | vs. SEA (WP: E.Santana; LP: F.Hernandez) | W - 2-1 | Wrap | Box |
| 8/098/098/098/098/10 | at NYY (WP: S.Downs; LP: M.Rivera) | W - 6-4 | Wrap | Box |
| 8/108/108/108/108/11 | at NYY (WP: I.Nova; LP: G.Richards) | L - 3-9 | Wrap | Box |
| 8/118/118/118/118/11 | at NYY (WP: R.Soriano; LP: F.Rodney) | L - 5-6 | Wrap | Box |
| 8/128/128/128/128/13 | at TOR (WP: E.Santana; LP: B.Morrow) | W - 5-1 | Wrap | Box |
| 8/138/138/138/138/13 | at TOR (WP: R.Romero; LP: J.Weaver) | L - 2-11 | Wrap | Box |
| 8/148/148/148/148/14 | at TOR (WP: J.Rauch; LP: F.Rodney) | L - 4-5 (10th) | Wrap | Box |
| 8/158/158/158/158/16 | vs. TEX (WP: A.Ogando; LP: B.Cassevah) | L - 4-8 | Wrap | Box |
| 8/168/168/168/168/17 | vs. TEX (WP: D.Holland; LP: T.Chatwood) | L - 3-7 | Wrap | Box |
| 8/178/178/178/178/18 | vs. TEX (WP: C.Wilson; LP: E.Santana) | L - 3-4 | Wrap | Box |
| 8/188/188/188/188/19 | vs. TEX (WP: H.Ramirez; LP: M.Adams) | W - 2-1 | Wrap | Box |
| 8/198/198/198/198/20 | vs. BAL (WP: D.Haren; LP: J.Reyes) | W - 8-3 | Wrap | Box |
| 8/208/208/208/208/21 | vs. BAL (WP: F.Rodney; LP: K.Gregg) | W - 9-8 (12th) | Wrap | Box |
| 8/218/218/218/218/21 | vs. BAL (WP: J.Williams; LP: B.Matusz) | W - 7-1 | Wrap | Box |
| 8/238/238/238/238/24 | vs. CWS (WP: J.Walden; LP: J.Frasor) | W - 5-4 | Wrap | Box |
| 8/248/248/248/248/25 | vs. CWS (WP: J.Weaver; LP: Z.Stewart) | W - 8-0 | Wrap | Box |
| 8/268/268/268/268/27 | at TEX (WP: D.Holland; LP: D.Haren) | L - 7-11 | Wrap | Box |
| 8/278/278/278/278/28 | at TEX (WP: E.Santana; LP: C.Wilson) | W - 8-4 | Wrap | Box |
| 8/288/288/288/288/29 | at TEX (WP: D.Oliver; LP: J.Weaver) | L - 5-9 | Wrap | Box |
| 8/298/298/298/298/30 | at SEA (WP: T.Wilhelmsen; LP: H.Takahashi) | L - 3-5 | Wrap | Box |
| 8/308/308/308/308/31 | at SEA (WP: J.Williams; LP: A.Vasquez) | W - 13-6 | Wrap | Box |
| 8/318/318/318/319/01 | at SEA (WP: F.Hernandez; LP: D.Haren) | L - 1-2 | Wrap | Box |
| September |
| 9/019/019/019/019/02 | at SEA (WP: E.Santana; LP: C.Furbush) | W - 4-3 | Wrap | Box |
| 9/029/029/029/029/03 | vs. MIN (WP: C.Pavano; LP: T.Chatwood) | L - 5-13 | Wrap | Box |
| 9/039/039/039/039/04 | vs. MIN (WP: J.Weaver; LP: P.Dumatrait) | W - 10-6 | Wrap | Box |
| 9/049/049/049/049/04 | vs. MIN (WP: J.Pineiro; LP: K.Slowey) | W - 4-1 | Wrap | Box |
| 9/059/059/059/059/06 | vs. SEA (WP: D.Haren; LP: A.Vasquez) | W - 7-3 | Wrap | Box |
| 9/069/069/069/069/07 | vs. SEA (WP: F.Hernandez; LP: E.Santana) | L - 1-2 | Wrap | Box |
| 9/079/079/079/079/08 | vs. SEA (WP: J.Williams; LP: C.Furbush) | W - 3-1 | Wrap | Box |
| 9/099/099/099/099/10 | vs. NYY (WP: J.Walden; LP: A.Laffey) | W - 2-1 | Wrap | Box |
| 9/109/109/109/109/11 | vs. NYY (WP: D.Haren; LP: C.Sabathia) | W - 6-0 | Wrap | Box |
| 9/119/119/119/119/11 | vs. NYY (WP: C.Wade; LP: E.Santana) | L - 5-6 | Wrap | Box |
| 9/129/129/129/129/13 | at OAK (WP: G.Gonzalez; LP: J.Pineiro) | L - 3-6 | Wrap | Box |
| 9/139/139/139/139/14 | at OAK (WP: H.Takahashi; LP: F.De Los Santos) | W - 6-3 | Wrap | Box |
| 9/149/149/149/149/14 | at OAK (WP: J.Weaver; LP: R.Harden) | W - 4-1 | Wrap | Box |
| 9/169/169/169/169/17 | at BAL (WP: T.Hunter; LP: D.Haren) | L - 3-8 | Wrap | Box |
| 9/179/179/179/179/18 | at BAL (WP: Z.Britton; LP: E.Santana) | L - 2-6 | Wrap | Box |
| 9/189/189/189/189/18 | at BAL (WP: J.Weaver; LP: A.Simon) | W - 11-2 | Wrap | Box |
| 9/199/199/199/199/20 | at TOR (WP: C.Janssen; LP: S.Downs) | L - 2-3 (10th) | Wrap | Box |
| 9/209/209/209/209/21 | at TOR (WP: J.Pineiro; LP: B.Cecil) | W - 10-6 | Wrap | Box |
| 9/219/219/219/219/22 | at TOR (WP: D.Haren; LP: D.McGowan) | W - 7-2 | Wrap | Box |
| 9/229/229/229/229/23 | at TOR (WP: S.Camp; LP: G.Richards) | L - 3-4 (12th) | Wrap | Box |
| 9/239/239/239/239/24 | vs. OAK (WP: G.Gonzalez; LP: J.Weaver) | L - 1-3 | Wrap | Box |
| 9/249/249/249/249/25 | vs. OAK (WP: J.Williams; LP: G.Moscoso) | W - 4-2 | Wrap | Box |
| 9/259/259/259/259/25 | vs. OAK (WP: F.De Los Santos; LP: J.Walden) | L - 5-6 | Wrap | Box |
| 9/269/269/269/269/27 | vs. TEX (WP: M.Hamburger; LP: D.Haren) | L - 3-4 | Wrap | Box |
| 9/279/279/279/279/28 | vs. TEX (WP: C.Lewis; LP: T.Chatwood) | L - 3-10 | Wrap | Box |
| 9/289/289/289/289/29 | vs. TEX (WP: M.Adams; LP: J.Walden) | L - 1-3 | Wrap | Box |