| San Diego Padres (27-48) at Houston Astros (31-43) |
| Game One |
San Diego 8, Houston 7 (10 innings) |
| Game Two |
Houston 5, San Diego 3 |
| Game Three |
Wednesday, June 27th, 8:05 p.m. |
| Game Four |
Thursday, June 28th, 8:05 p.m. |
| Records |
| 2012 Head-to-Head Record |
Tied 1-1 (0-0 at SD; 1-1 at Hou) |
| 2011 Head-to-Head Record |
San Diego 5-3 (3-1 at SD; 2-2 at Hou) |
| 2010 Head-to-Head Record |
San Diego 5-2 (3-1 at SD; 2-1 at Hou) |
| 2009 Head-to-Head Record |
Houston 6-1 (3-1 at SD; 3-0 at Hou) |
| Home Record |
San Diego 16-24; Houston 22-18 |
| Away Record |
San Diego 11-24; Houston 9-25 |
| Current Streak |
San Diego (L1); Houston (W1) |
| Record vs. Central Division |
San Diego 4-10 |
| Record vs. Western Division |
Houston 6-12 |
| 2012 Meetings |
| 6/25 - San Diego, 8-7 (10) (at Hou - WP: Thayer; LP: Lyon) |
| 6/26 - Houston, 5-3 (at Hou - WP: Lyles; LP: K.Wells) |
| 2011 Meetings |
| 4/14 - Houston, 1-0 (at Hou - WP: Norris; LP: Moseley) |
| 4/15 - San Diego, 4-2 (at Hou - WP: Harang; LP: Happ) |
| 4/16 - Houston, 5-3 (at Hou - WP: Melancon; LP: Latos) |
| 4/17 - San Diego, 8-6 (at Hou - WP: Frieri; LP: Melancon) |
| 6/02 - Houston, 7-4 (at SD - WP: Norris; LP: Stauffer) |
| 6/03 - San Diego, 3-1 (at SD - WP: Moseley; LP: Happ) |
| 6/04 - San Diego, 6-3 (at SD - WP: Harang; LP: A.Rodriguez) |
| 6/05 - San Diego, 7-2 (at SD - WP: Latos; LP: Lyles) |
| 2010 Meetings |
| 5/07 - San Diego, 7-0 (at Hou - WP: Latos; LP: Norris) |
| 5/08 - San Diego, 2-1 (at Hou - WP: Garland; LP: Paulino) |
| 5/09 - Houston, 4-3 (11) (at Hou - WP: Lyon; LP: R.Webb) |
| 7/01 - Houston, 6-3 (10) (at SD - WP: Sampson; LP: Gregerson) |
| 7/02 - San Diego, 3-0 (at SD - WP: Latos; LP: Lyon) |
| 7/03 - San Diego, 1-0 (at SD - WP: Adams; LP: G.Chacin) |
| 7/04 - San Diego, 3-2 (at SD - WP: H.Bell; LP: Lyon) |
| 2009 Meetings |
| 5/08 - Houston, 2-0 (at Hou - WP: W.Rodriguez; LP: Gaudin) |
| 5/09 - Houston, 5-4 (at Hou - WP: Hawkins; LP: Gregerson) |
| 5/10 - Houston, 12-5 (at Hou - WP: Oswalt; LP: Geer) |
| 6/29 - Houston, 3-1 (at SD - WP: Oswalt; LP: Geer) |
| 6/30 - San Diego, 4-3 (at SD - WP: Banks; LP: Sampson) |
| 7/01 - Houston, 7-1 (at SD - WP: Moehler; LP: W.Silva) |
| 7/02 - Houston, 7-2 (at SD - WP: W.Rodriguez; LP: Correia) |
| San Diego last five games |
Houston last five games |
| 6/22 - W vs. Seattle, 9-5 |
6/22 - L vs. Cleveland, 0-2 |
| 6/23 - L vs. Seattle, 1-5 |
6/23 - W vs. Cleveland, 8-1 |
| 6/24 - W vs. Seattle, 2-0 |
6/24 - W vs. Cleveland, 7-1 |
| 6/25 - W at Houston, 8-7 (10) |
6/25 - L vs. San Diego, 7-8 (10) |
| 6/26 - L at Houston, 3-5 |
6/26 - W vs. San Diego, 5-3 |