Syracuse, NY (Sports Network) - Luke Hancock's third 3-pointer of the second half put Louisville ahead to stay in the final minute and the 10th-ranked Cardinals pulled out a 58-53 win over No. 12 Syracuse at the Carrier Dome.

Hancock hit four from beyond the arc overall and finished with 12 points for Louisville (24-5, 12-4 Big East), which has won five straight and avenged a 70-68 home loss to Syracuse in January.

Louisville was No. 1 when the Orange scored the final four points to steal that game. This time, the Cardinals took it from Syracuse (22-7, 10-6) in the final minute.

Hancock drilled a three from the left wing with 53 seconds left to snap a 48-48 tie and the Orange couldn't answer.

Michael Carter-Williams, who led Syracuse's charge back from a seven-point deficit, missed badly on a 3-point try and Russ Smith hit two from the line to extend the Louisville lead to five. The Orange then turned it over and Kevin Ware made a free throw with 23 seconds to play.

Brandon Triche canned two from the line with 16 seconds left to pull Syracuse within four and the Orange nearly came up with a steal on the inbound pass but lost the ball out of bounds. Louisville successfully inbounded the ball and Ware made two more free throws to restore a six-point margin before C.J. Fair drained a three with seven seconds remaining.

Smith was fouled with 3.4 seconds to play and calmly sank two from the stripe to seal it.

Fair scored 19 points to lead Syracuse, which has lost three in a row for the first time since a four-game skid from Jan. 17-29, 2011. The Orange have also dropped two straight at the Carrier Dome after having their 38-game home winning streak stopped last Saturday with a loss to Georgetown.

03/02 14:23:29 ET