| Houston Astros (33-56) at San Diego Padres (36-54) |
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| Game One |
Monday, July 16th, 10:05 p.m. |
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| Game Two |
Tuesday, July 17th, 10:05 p.m. |
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| Game Three |
Wednesday, July 18th, 3:35 p.m. |
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| Game Four |
Thursday, July 19th, 10:05 p.m. |
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| Records |
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| 2012 Head-to-Head Record |
Tied 2-2 (2-2 at Hou; 0-0 at SD) |
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| 2011 Head-to-Head Record |
San Diego 5-3 (2-2 at Hou; 3-1 at SD) |
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| 2010 Head-to-Head Record |
San Diego 5-2 (2-1 at Hou; 3-1 at SD) |
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| 2009 Head-to-Head Record |
Houston 6-1 (3-0 at Hou; 3-1 at SD) |
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| Home Record |
Houston 24-21; San Diego 17-27 |
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| Away Record |
Houston 9-35; San Diego 19-27 |
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| Current Streak |
Houston (L4); San Diego (W2) |
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| Record vs. Western Division |
Houston 7-16 |
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| Record vs. Central Division |
San Diego 6-14 |
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| 2012 Meetings |
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| 6/25 - San Diego, 8-7 (10) (at Hou - WP: Thayer; LP: Lyon) |
| 6/26 - Houston, 5-3 (at Hou - WP: Lyles; LP: K.Wells) |
| 6/27 - Houston, 1-0 (at Hou - WP: Harrell; LP: Richard) |
| 6/28 - San Diego, 7-3 (at Hou - WP: Vincent; LP: Myers) |
| 2011 Meetings |
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| 4/14 - Houston, 1-0 (at Hou - WP: Norris; LP: Moseley) |
| 4/15 - San Diego, 4-2 (at Hou - WP: Harang; LP: Happ) |
| 4/16 - Houston, 5-3 (at Hou - WP: Melancon; LP: Latos) |
| 4/17 - San Diego, 8-6 (at Hou - WP: Frieri; LP: Melancon) |
| 6/02 - Houston, 7-4 (at SD - WP: Norris; LP: Stauffer) |
| 6/03 - San Diego, 3-1 (at SD - WP: Moseley; LP: Happ) |
| 6/04 - San Diego, 6-3 (at SD - WP: Harang; LP: A.Rodriguez) |
| 6/05 - San Diego, 7-2 (at SD - WP: Latos; LP: Lyles) |
| 2010 Meetings |
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| 5/07 - San Diego, 7-0 (at Hou - WP: Latos; LP: Norris) |
| 5/08 - San Diego, 2-1 (at Hou - WP: Garland; LP: Paulino) |
| 5/09 - Houston, 4-3 (11) (at Hou - WP: Lyon; LP: R.Webb) |
| 7/01 - Houston, 6-3 (10) (at SD - WP: Sampson; LP: Gregerson) |
| 7/02 - San Diego, 3-0 (at SD - WP: Latos; LP: Lyon) |
| 7/03 - San Diego, 1-0 (at SD - WP: Adams; LP: G.Chacin) |
| 7/04 - San Diego, 3-2 (at SD - WP: H.Bell; LP: Lyon) |
| 2009 Meetings |
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| 5/08 - Houston, 2-0 (at Hou - WP: W.Rodriguez; LP: Gaudin) |
| 5/09 - Houston, 5-4 (at Hou - WP: Hawkins; LP: Gregerson) |
| 5/10 - Houston, 12-5 (at Hou - WP: Oswalt; LP: Geer) |
| 6/29 - Houston, 3-1 (at SD - WP: Oswalt; LP: Geer) |
| 6/30 - San Diego, 4-3 (at SD - WP: Banks; LP: Sampson) |
| 7/01 - Houston, 7-1 (at SD - WP: Moehler; LP: W.Silva) |
| 7/02 - Houston, 7-2 (at SD - WP: W.Rodriguez; LP: Correia) |
| Houston last five games |
San Diego last five games |
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| 7/07 - W vs. Milwaukee, 6-3 |
7/07 - L vs. Cincinnati, 5-6 |
| 7/08 - L vs. Milwaukee, 3-5 (10) |
7/08 - L vs. Cincinnati, 2-4 |
| 7/13 - L at San Francisco, 1-5 |
7/13 - L at Los Angeles, 1-2 |
| 7/14 - L at San Francisco, 2-3 (12) |
7/14 - W at Los Angeles, 7-6 |
| 7/15 - L at San Francisco, 2-3 |
7/15 - W at Los Angeles, 7-2 |