Oakland, CA (Sports Network) - Oakland Raiders running back Darren McFadden will miss a second consecutive game when the team hosts the New Orleans Saints this coming Sunday.

McFadden reportedly suffered a high ankle sprain during the first half of Oakland's Nov. 4 matchup with Tampa Bay and was inactive for last Sunday's loss at Baltimore. The Raiders ruled the oft-injured back out for the New Orleans game on Friday after he sat out a third consecutive practice.

Backup Mike Goodson, also dealing with a sprained ankle, was also declared out for a second straight week, meaning Marcel Reece will likely again serve as the lead back against the Saints.

Reece finished with 48 yards on 13 carries in Oakland's 55-20 setback to the Ravens, while adding 56 yards on a team-high seven catches.

Oakland also won't have veteran defensive tackle Richard Seymour for Sunday's contest due to knee and hamstring injuries, while wide receiver Darrius Heyward-Bey (hamstring) and safety Tyvon Branch (neck) were listed as questionable.

Heyward-Bey did not practice on Thursday or Friday, while Branch was a limited participant on Friday.

11/16 17:58:12 ET