|
| 1st Quarter |
|
| Buffalo at 14:55 |
| | John Potter kicked off 68 yards from the Buffalo 35 to the San Francisco -3. Kyle Williams to the San Francisco 14 for 17 yards. |
| San Francisco at 14:55 |
| 1st and 10 at SFX 14 | Frank Gore rushed to the San Francisco 19 for 5 yards. |
| 2nd and 5 at SFX 19 | Alex Smith pass to Michael Crabtree to the San Francisco 23 for 4 yards. |
| 3rd and 1 at SFX 23 | Offensive penalty on San Francisco, Mike Iupati, Holding/Illegal Use of Hands, 10 yards, enforced at the San Francisco 23. |
| 3rd and 11 at SFX 12 | Alex Smith pass to Mario Manningham to the San Francisco 22 for 10 yards. |
| 4th and 1 at SFX 22 | Andy Lee punted 58 yards from the San Francisco 22 to the Buffalo 20. Leodis McKelvin returned to the Buffalo 48 for 28 yards. |
| Buffalo at 12:02 |
| 1st and 10 at BUF 48 | Offensive penalty on Buffalo, Jairus Byrd, Holding/Illegal Use of Hands, 10 yards, enforced at the Buffalo 48. |
| 1st and 10 at BUF 38 | Fred Jackson rushed to the Buffalo 42 for 4 yards. |
| 2nd and 6 at BUF 42 | Fred Jackson rushed to the Buffalo 41 for -1 yards. |
| 3rd and 7 at BUF 41 | Ryan Fitzpatrick pass incomplete to Stevie Johnson. |
| 4th and 7 at BUF 41 | Shawn Powell punted into the end zone for a touchback. |
| San Francisco at 10:42 |
| 1st and 10 at SFX 20 | Frank Gore rushed to the San Francisco 39 for 19 yards. |
| 1st and 10 at SFX 39 | Alex Smith pass to Vernon Davis to the Buffalo 8 for 53 yards. |
| 1st and 8 at BUF 8 | Frank Gore rushed to the Buffalo 1 for 7 yards. |
| 2nd and 1 at BUF 1 | Frank Gore rushed for no gain. |
| 3rd and 1 at BUF 1 | Frank Gore rushed for no gain. |
| 4th and 1 at BUF 1 | 19-yarder by David Akers. |
| | David Akers kicked off 68 yards from the San Francisco 35 to the Buffalo -3. Leodis McKelvin to the San Francisco 44 to the San Francisco 44 for 59 yards. |
| Buffalo at 7:10 |
| 1st and 10 at SFX 44 | Ryan Fitzpatrick pass to Stevie Johnson to the San Francisco 37 for 7 yards. |
| 2nd and 3 at SFX 37 | Fred Jackson rushed to the San Francisco 33 for 4 yards. |
| 1st and 10 at SFX 33 | Ryan Fitzpatrick pass incomplete to Stevie Johnson. |
| 2nd and 10 at SFX 33 | C.J. Spiller rushed to the San Francisco 38 for -5 yards. |
| 3rd and 15 at SFX 38 | Ryan Fitzpatrick pass to Brad Smith to the San Francisco 37 for 1 yard. |
| 4th and 14 at SFX 37 | Shawn Powell punted the ball 24 yards, out of bounds at the San Francisco 13. |
| San Francisco at 4:00 |
| 1st and 10 at SFX 13 | Alex Smith pass to Michael Crabtree to the San Francisco 32 for 19 yards. |
| 1st and 10 at SFX 32 | Offensive penalty on San Francisco, Joe Staley, False Start, 5 yards, enforced at the San Francisco 32. |
| 1st and 15 at SFX 27 | Kyle Williams on an end around to the San Francisco 33 for 6 yards. |
| 2nd and 9 at SFX 33 | Offensive penalty on San Francisco, Frank Gore, Illegal Block, 15 yards, enforced at the San Francisco 33. |
| 2nd and 24 at SFX 18 | Alex Smith pass incomplete to Kendall Hunter. |
| 3rd and 24 at SFX 18 | Alex Smith pass to Michael Crabtree to the San Francisco 34 for 16 yards. |
| 4th and 8 at SFX 34 | Andy Lee punt downed by kicking team at the Buffalo 12 for 54 yards. |
| Buffalo at 0:52 |
| 1st and 10 at BUF 12 | C.J. Spiller rushed to the Buffalo 16 for 4 yards. |
| 2nd and 6 at BUF 16 | Ryan Fitzpatrick pass to Donald Jones to the Buffalo 24 for 8 yards. |
| 1st and 10 at BUF 24 | Ryan Fitzpatrick pass to Stevie Johnson to the Buffalo 38 for 14 yards. |
| 1st and 10 at BUF 38 | End of 1st quarter. |
